| Mechanisms of action and classification |
Starting dose |
Standard dose |
Lethality in overdose |
Insomnia and agitation |
Sedation |
Nausea or gastro-intestinal effects |
Sexual dysfunction |
Weight gain |
| mg/day |
| Selective serotonin-reuptake inhibitors (SSRIs) |
| Paroxetine (Paxil) |
20 |
20-40 |
low |
+ |
- or + |
+ |
+ |
+ |
| Sertraline (Zoloft) |
50 |
50-150 |
low |
+ |
- or + |
+ |
+ |
+ |
| Citalopram (Celexa) |
20 |
20-40 |
low |
+ |
- or + |
+ |
+ |
+ |
| Mixed or dual-action reuptake inhibitors |
| Venlafaxine (Efexor) |
37-75 |
75-225 |
moderate |
+ |
- or + |
+ |
+ |
- or + |
| Mixed-action newer agents |
Mirtazapine (Remeron)
(5-HT2 plus 5-HT3 plus α2-adrenergic receptors) |
30 |
30-60 |
low |
- or + |
++ |
- or + |
- or + |
++ |