Index - 28 - 29 - 30/31 - 32/33/34 - 35 - 36/37/38/39 - 40/41 - 42/43 - 44/45/46 - 47/48 - 49 - 50/51/52/53
54/55 - 56 - 57/58 - 59 - 60/61 - 62 - Pages online: A - B - C - D - E - F - G - References
CLASSIFICATION, DOSES, SAFETY AND SIDE EFFECTS OF ANTIDEPRESSANTS
Mechanisms of action and classification Starting dose Standard dose Lethality in overdose Insomnia and agitation Sedation Nausea or gastro-intestinal effects Sexual dysfunction Weight gain
mg/day
Selective serotonin-reuptake inhibitors (SSRIs)
Paroxetine (Paxil) 20 20-40 low + - or + + + +
Sertraline (Zoloft) 50 50-150 low + - or + + + +
Citalopram (Celexa) 20 20-40 low + - or + + + +
Mixed or dual-action reuptake inhibitors
Venlafaxine (Efexor) 37-75 75-225 moderate + - or + + + - or +
Mixed-action newer agents
Mirtazapine (Remeron)
(5-HT2 plus 5-HT3 plus α2-adrenergic receptors)
30 30-60 low - or + ++ - or + - or + ++
- = none;  + = moderate; ++ = severe