Index - 28 - 29 - 30/31 - 32/33/34 - 35 - 36/37/38/39 - 40/41 - 42/43 - 44/45/46 - 47/48 - 49 - 50/51/52/53
54/55 - 56 - 57/58 - 59 - 60/61 - 62 - Pages online: A - B - C - D - E - F - G - References
CNS PENETRATION OF ANTIRETROVIRAL DRUGS
CNS penetrability of antiretroviral drugs i
Class Good Moderate Low
NRTIs Abacavir
Emtricitabine
Zidovudine
Lamivudine
Stavudine
Didanosine
Tenofovir
NNRTIs Nevirapine Efavirenz  
PIs Indinavir
Indinavir/r
Lopinavir/r
Atazanavir
Atazanavir/r
Fosamprenavir/r
Darunavir/r
Fosamprenavir
Ritonavir
Saquinavir
Saquinavir/r
Tipranavir/r
Fusion inhibitors     Enfuvirtide
i Limited information on all drugs listed; this chart will be regularly updated as new data emerges. Drugs listed as having a “low” penetrability may have no penetrability at all in patients with normal blood-brain barrier. Very limited data on newer drugs such as etravirine, raltegravir and maraviroc suggests that these agents have limited penetration into the CNS.